Loss of epigenetic regulators causes mental retardation
New findings, published in recent issues of Neuron and Science, indicate that malfunction of a protein complex that normally suppresses gene activation causes mental retardation in mice and humans and...
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Mouse model reveals a cause of ADHD
New research in a mouse model of attention deficit/hyperactivity disorder suggests that the root of the psychiatric disorder might be the over-activity of a protein that regulates the brain’s...
View ArticleLeslie Vosshall, Paul Greengard win Dart/NYU biotech awards
Rockefeller scientists receive honors for their contributions to next-generation insect repellents and drugs to treat neurological diseases. More »
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Scientists identify potential new target for schizophrenia drugs
A protein that boosts the signaling power of a receptor involved in relaying messages between brain cells may provide a new target for the development of treatments for schizophrenia and Parkinson’s...
View ArticleAlzheimer’s brain protein may provide target for treating mental retardation
Reducing the level of β-amyloid, a protein found in the brains of patients with Alzheimer’s disease and Down syndrome, may improve the cognitive abilities of children with Down syndrome. The new study...
View ArticleMicroRNAs play a role in cocaine addiction
MicroRNAs, short stretches of RNA that silence genes, have already been linked to cancer, heart disease and mental disorders such as schizophrenia. New research by Rockefeller University scientists...
View ArticlePaul Greengard receives Karolinska Institutet’s Bicentennial Gold Medal
The gold medal is the highest award conferred by the Karolinska Institutet, one of the world’s leading medical universities, during its 200th anniversary celebrations. The medal recognizes the work of...
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Molecule that spurs cell’s recycling center may help Alzheimer’s patients
A molecule that activates the cell’s natural recycling program may flush away the protein fragments that accumulate and form senile plaques in Alzheimer’s disease. New research suggests that...
View ArticleAnti-inflammatory drugs reduce effectiveness of SSRI antidepressants
Scientists have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective...
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New research sheds light on the molecular origins of Parkinson’s disease
Scientists have identified two proteins that appear to have a protective effect in the set of neurons most affected by this degenerative disease. When the activity of these molecules wanes, disease...
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A newly discovered molecular feedback process may protect the brain against...
Researchers have identified within neurons a series of molecular interactions — known as a pathway — that can dampen the production of the Alzheimer’s protein amyloid-β. These results suggest a new...
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Study offers insight on how a new class of antidepressants works
The experimental drugs target brain cells’ ability to respond to the chemical messenger glutamate, however, it has been unclear how they work. The recent discovery of a molecular amplification system...
View ArticleIn the News – Scientific American – Greengard turns 90
A Nobel Laureate Turning 90 Continues to Churn Out Ideas for New Drugs “Paul Greengard has been busy. In August he co-authored a paper on molecules that appear to regulate genes that might protect...
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New approach exposes 3D structure of Alzheimer’s proteins within the brain
Using an approach that makes brain tissue transparent, researchers were able to view clumps of the toxic protein amyloid-β from multiple angles within mouse and human brains. More »
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Mouse studies offer new insights about cocaine’s effect on the brain
Researchers have determined how a specific protein regulates the brain’s response to cocaine. Their findings provide fresh insights into the neurobiology of addiction, and could lead to the development...
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